Gene Variants Linked to Lung Cancer Identified
Summary from multiple countries, from articles in English
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People who inherit a particular genetic variant are 30 per cent more likely to develop lung cancer than those who do not; in those who inherit two copies of the variant, the risk rises by up to 80 per cent. (article 6)
The largest of the studies, from deCODE Genetics, an Icelandic company, found that the increased risk occurs entirely because the variant makes smokers more likely to become addicted and to smoke more heavily. (article 6)
A smoker who inherits these genetic variations from both parents has an 80 percent greater chance of lung cancer than a smoker without the variants, the researchers reported. (article 1)
However, whether these gene variants represent a direct risk for lung cancerandincreased susceptibility to smoking isn't clear, according to two studies published in the April 3 edition ofNatureand one published in the April 2 online edition ofNature Genetics. (article 2)
The discovery by three separate teams of scientists makes the strongest case so far for the biological underpinnings of the addiction of smoking and sheds light on how genetics and cigarettes join forces to cause cancer, experts said. (article 4)
Current or former smokers who carry two copies of both variants, one from each parent - about 15% of the total - have a raised risk of 70-80%. (article 3)
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Other summaries about this story:
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Story keywords
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Lung, cancer, Smokers, smoking, variants |
Source articles
- Genetic Link Tied to Smoking Addiction (Washington Post, 04/02/2008, 385 words)
- Gene Variants Linked to Lung Cancer Identified (Washington Post, 04/02/2008, 640 words)
- Genetic link to smoking addiction (BBC News, 04/02/2008, 470 words)
- Genetics linked to smoking dependency, addiction (dallasnews.com, 04/02/2008, 716 words)
- Studies find genes that increase risk of lung cancer (boston.com, 04/03/2008, 665 words)
- New treatments hope after 'lung cancer gene' found (timesonline.co.uk, 04/03/2008, 591 words)
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